CHEMISTRY-2020

Anti-Cancer Medicinal Chemistry

The term "cancer" refers to a group of diseases that involve abnormal cell growth with the potential to spread to different parts of the body. As each cancer consists of a variety of different cell types highly effective at developing resistance to each drug and radiation therapy, it is a particularly difficult disease to treat. The challenge for the sector of medicinal chemistry is to design drugs capable of selectively targeting cancer cells while avoiding multidrug resistance pathways. Medicinal Chemistry is  following anti-tumour agents of high specificity to help design suitably targeted, selective chemotherapeutics. Current programs involve a diverse array of anti-cancer targets, like lipid and protein kinases, microtubules, topoisomerases, hypoxia inducible factors, bromodomains and histone acetyltransferases.